Compared to Mounjaro, which also promotes weight loss, Semaglutide has a similar impact on ALT reduction. Both drugs improve liver enzymes by reducing fat and inflammation, but Semaglutide’s longer track record provides more data on liver outcomes.

There are no strict dietary restrictions with Mounjaro, but eating balanced, nutrient-rich meals helps the medication work most effectively. Many people find smaller portions and lighter meals are easier to tolerate, especially early on. Limiting high-fat, spicy, or overly rich foods can also reduce nausea and improve comfort while your body adjusts. Why diet still matters with Mounjaro NICE (TA1026, 2025) and NHS guidance both stress that Mounjaro should be used alongside a

At the moment, there is no generic version of Mounjaro available. The medication is still under patent protection, meaning only Eli Lilly can produce tirzepatide until that period ends. Generic versions may become available in future years, once regulatory timelines and patent conditions allow. Understanding what “generic” means A generic medicine is an equivalent version of a branded drug that becomes available once patent and exclusivity rights expire. It must contain the s

A major new review has pitted the big three weight management products against each other – it looks at comparing the weight lost with each product and how long users were able to maintain their weight loss. There are several weight loss treatments now available in the UK via the NHS and private clinics Scientists compar ed tirzepatide – the active ingredient of Mounjaro – to semaglutide, which is in Wegovy and Ozempic, and liraglutide, that’s in Saxenda. he reviews – publish

Mounjaro was developed by the pharmaceutical company Eli Lilly and first approved for medical use in 2022. It’s based on years of research into dual hormone therapies that target both GIP and GLP-1 pathways. Its effectiveness has since been demonstrated in large international trials, helping establish it as a new generation of treatment for type 2 diabetes and weight management. How Mounjaro began The story of Mounjaro started in the early 2010s, when researchers explored way

Mounjaro doesn’t “speed up” metabolism in the traditional sense, but it improves how your body processes glucose and stores energy. By enhancing insulin sensitivity and reducing appetite, it helps the body use energy more efficiently. Over time, this balance can lead to gradual fat loss and better overall metabolic health. How Mounjaro supports metabolic function Metabolism is the body’s process of converting food into energy. NICE (TA1026, 2025) explains that tirzepatide — t

Mounjaro is not usually prescribed alongside other weight-loss injections or tablets, as combining treatments that affect similar hormone pathways could increase side effects or complications. Doctors generally recommend using it as a single therapy so its effects can be properly monitored. If you’re already on another weight management medication, your clinician will advise whether it’s best to pause or switch before starting Mounjaro. Why Mounjaro is used alone NICE (TA1026

Mounjaro works by activating areas in the brain that sense fullness and regulate food intake. This helps reduce appetite while enhancing satiety, meaning you feel content with less food. Over time, it can help reshape eating patterns by supporting a more natural balance between hunger and satisfaction. The science behind hunger control Appetite control depends on communication between the gut and the brain. After eating, the body releases two hormones — GLP-1 (glucagon-like p

In the early weeks, it’s common to notice reduced appetite and mild digestive effects such as nausea, bloating, or fatigue. These reactions usually improve as your body adjusts to the treatment and dose increases gradually. Keeping meals light, staying hydrated, and avoiding rich or spicy foods can make the transition smoother. Understanding your body’s early reactions NICE and NHS guidance describe the first month of Mounjaro treatment as a period of adjustment rather than r

Evidence suggests Mounjaro can support sustained weight loss when used alongside lasting lifestyle changes. Long-term studies show participants maintained significant reductions in both weight and blood sugar over a year or more of treatment. Continued success depends on consistency, as stopping the medication may lead to weight regain if healthy habits aren’t maintained. What the long-term trials show The main long-term evidence comes from the SURMOUNT-1 and SURMOUNT-4 studi

Wegovy is compatible with vegetarian or vegan eating, but plan protein (beans, lentils, tofu/tempeh, mycoprotein), iron, iodine, calcium and B12 carefully — lower appetite can make hitting targets harder. A simple “protein first” rule at meals and a daily multivitamin that fits your diet can help, alongside routine blood work if your clinician advises. For coeliac disease or other medical diets, your team will integrate Wegovy around the existing plan rather than replace it.

Yes — psychological context matters. Calmer appetite can ease emotional or stress-linked eating, but it doesn’t replace mental-health care. Set expectations early, watch for mood changes, and use behavioural tools (meal planning, mindful eating, sleep routines). If you’ve had disordered-eating patterns, tell your clinician so support can be tailored; brief check-ins with a dietitian or counsellor often make the process smoother. Why psychology is part of treatment Weight mana

There are no strict activities to avoid, but comfort improves if you skip very hot environments (saunas, hot tubs) and high-intensity core work for a few hours after injecting a tender area. If you feel queasy on escalation weeks, keep meals light, postpone vigorous workouts until later in the day, and limit alcohol. Don’t massage the injection site; a cool pack helps if it stings. If dizziness or reflux appears, avoid driving until you feel steady and speak with your team ab

Yes — for older adults, start low, go slow, and protect muscle. Appetite reduction plus low protein can increase frailty risk, so set a protein target and add light resistance work if feasible. Review other medicines for dizziness or dehydration risk, and monitor renal function and blood pressure routinely. Services may schedule closer follow-up for people living with frailty or multiple conditions. Why Wegovy requires extra care in older adults Wegovy (semaglutide) can be us

Signs include no change in appetite, cravings as frequent as before, or weight not trending down across reviews despite steady use....

Contact your clinic or GP well before the final dose in your pen so there’s time to process repeats and navigate any supply constraints....

No — pregnancy and breastfeeding are not recommended with Wegovy. Women of child-bearing potential should use effective contraception and...

Not at present — genetic or metabolic profiling isn’t used to set Wegovy doses in UK services. Dosing is “treat-to-tolerate” and...

Follow-up typically includes regular weight checks, symptom review, pulse and blood pressure, and a look at your food/activity plan. Many...

Brief tingling or numbness can occur from needle irritation and usually fades quickly. Persistent numbness, marked pain, colour changes,...