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Saxenda (Liraglutide)
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You may have seen the press coverage about this medication since 2017 when it was first touted as the SkinnyJab.Saxenda has shown promising weight loss results in clinical trials and was the first of it's kinda back in 2017.Containing the active ingredient Liraglutide, it works on our GLP-1 receptors to initiate weight loss via several methods.
The medication mimics a natural hormone already found in your body (GLP-1). It works in three key ways to reduce your appetite. It blocks a key hunger hormone telling your brain that you are hungry, whilst also helping to reduce leptin resistance (a hormone which can help off-set weight gain by increasing satiety aka fullness, and speed up your metabolism to help regulate the levels of fatty tissue in your body). This also helps stop the weight from coming straight back on when you stop the jab.It slows down the gastric emptying process, meaning that your body takes longer to process food and it is fuller for longer. This means your body does not need as much intake as normal as it works off the food it has.The medication helps to speed up your metabolism and increase fat burning by reducing glucagon & reducing insulin resistance. This promotes normal blood glucose levels, the liver metabolism of glucose and helps adipose tissue burn fat in a safe and controlled method without causing a sugar-crash. This avoids the urges for quick-fix sugary foods.
The medication comes as a pre-filled injectable pen. You inject yourself in an area where you can pinch a good amount of meat (aka subcutaeneous fat).This can be the stomach area, the notorious love handle areas, top of the thighs or even the bottom! You use a CLEAN and NEW needle every day, disposing of the needle after each injection.Your starting dose is usually 0.6mg per day and any changes in your dosing will be reviewed regularly as your body adjusts to the medication.Remember to rotate the injection site each day to avoid irritating your skin or causing a build up of the medication in one area.
The starting dose is is 0.6mg per day.Official titration guidelines from the manufacturer then recommend increasing your dose every 7 days, however we will only titrate you up the doses if it is clinically appropriate and safe to do so. You may find a lower dose works well for you.We’ll always start you on the lowest dose and slowly build up to help your body adjust, a process known as titration. Below is what your treatment plan could look like:Weeks 1: 0.6mg dailyWeek 2: 1.2mg dailyWeek 3: 1.8mg dailyWeek 4: 2.4mg dailyWeek 5: 3mg daily (maximum dose)As you increase the dose, you will use more of the medication up within the pen.Each Saxenda pen contains 18mg/3ml, which is 18mg worth of medication in 3ml worth of solution. Using 3mg per day would equate to 6 days/doses worth in an 18mg/3ml pen.
Saxenda pens come as a pre-filled syringe. The key difference with Saxenda compared to other injectables such as Wegovy, is that Saxenda has different dose settings on the same pen i.e. 0.6mg, 1.2mg, 1.8mg, 2.4mg and 3mg doses can be dialled up and administered each day.Each pen contains 18mg worth of medication in a total of 3ml solution. Ignoring the 3ml solution part, it is easier to calculate how many days/doses you can get out of a Saxenda pen.For example, using 3mg per day would equate to 6 days/doses worth with 18mg in the pen (18mg divided by 3mg = 6 doses).Below is a rough estimated guide, but this will vary depending on whether you increase your dose at any point and what day you increase it on.0.6mg per day30 days / doses1.2mg per day15 days / doses1.8mg per day10 days / doses2.4mg per day7.5 days / doses3mg per day6 days / doses
The medication can be used for those with a BMI over 25. We take into account a range of factors such as:BMIMedical HistoryCurrent MedicationBody measurementsEating habitsPast dietsCurrent exercise levelsYou shouldn’t use Saxenda if you’re pregnant or breast feeding, and you should stop taking Saxenda at least one month before trying to get pregnant.Saxenda is not suitable in some medical circumstances, for example if you use some other diabetes medicines, have severe problems with digesting food, or have a history of pancreatitis or thyroid cancer. If you’re allergic to liraglutide or any of the other ingredients in this weight loss injection treatment, you must not use Saxenda.It’s essential that you give us a full medical history and details of any conditions or other medicines you’re taking when you fill out our online questionnaire. This ensures we’re able to prescribe weight loss treatment that’s suitable and safe for you.
Like any new medication introduced to your body, your body will have to adjust to it. Some people get mild side effects, such as headaches, nausea, dry mouth or tiredness. These side effects are generally mild and are transient - which means they will go after a few days once your body has adjusted.We will send you aftercare information on how to deal with any potential side effects, along with the Patient Information Leaflet which goes into greater detail.Everyone is different. You may not experience any side effects, you may experience one side effect or several side effects. Common Side Effects:NauseaHeadachesDry MouthConstipationLoose StoolTirednessStomach CrampsPlease do not hesitate to contact us if you need any support on dealing with side effects. We are more than happy to advise you.Adverse Effects:Adverse effects are rare but they are something you should be aware of.Adverse effects may include:Palpitations / Fast Heart RatePancreatitisIf you experience or feel that you may be experiencing these adverse effects, please stop using the medication & contact 111. When you are safe to do so, please contact us.Anaphylaxis:There have been no documented cases of an anaphylactic reaction to Liraglutide, Dulaglutide or Semaglutide but as this is a new medication being introduced to your body, we want to make you aware of the possible signs of anaphylaxis.If you experience swelling of the lips/tongue/throat, difficulty breathing, tightness in the chest, a severe rash or severe itching, discontinue use immediately and call 999.
Common side effects should be mild and are likely to lessen or even disappear after your body gets used to the treatment. We understand that it’s still tough to live with these discomforts though and so we’ve put together some tips for managing these where possible:Make sure to inject yourself with the treatment at the same time and day each week so your body has a regular interval between each doseStay hydrated, sipping water and other clear liquids if you’re experiencing nausea, vomiting or diarrhoea. It may also help to eat smaller meals more regularly and avoid anything that smells or tastes too strongIf you’re struggling with constipation, increase your fibre intake, stay well hydrated and try eating small fruits such as prunes, figs or grapes. Make sure you’re also getting regular activity, such as going on short walksTo ease a headache, spend time in a quiet space to relax, take a simple pain relief medicine like paracetamol, drink plenty of water, and try relaxation techniques such as meditation and DIY scalp massage For more information on managing side effects and what to do if you experience more severe side effects, see our dedicated aftercare page for our customers.
During clinical trials by the manufacturer, the average weight loss has been calculated as between 8lbs and 15lbs. Everyone is different, so your weight loss may be more or less. Try not to compare yourself to others losing weight - focus on yourself, your goals and your progress. - your safety is paramount.
Saxenda is not suitable for everyone.You should not take Saxenda if:you're allergic to semaglutide or any of the other listed ingredientsyou've previously had a serious allergic reaction to semaglutide or any of the ingredients in Wegovyyou or a close family member has ever had medullary thyroid carcinoma (MTC), a type of thyroid canceryou have multiple endocrine neoplasia syndrome type 2 (MEN 2)Are 75 years old or overPlease tell us before starting treatment if you:have or have had problems with your pancreas or kidneyshave type 2 diabetes with a history of diabetic retinopathyare due to have surgery or a procedure involving anaesthesiaare pregnant or planning to become pregnant. Saxenda may harm your unborn baby, so you should stop taking it at least two months before trying to conceiveare breastfeeding or planning to breastfeed. Breastfeeding isn't recommended while taking SaxendaTell us about all medications you take, including prescription medicines, over-the-counter treatments, vitamins and supplements. Saxenda can affect how some medicines work, and some medicines can affect how Saxenda govy works.This is especially important if you take diabetes medications like insulin or sulfonylureas, as using Saxenda alongside these treatments increases your risk of hypoglycaemia.
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